Neuregulin links dopaminergic and glutamatergic neurotransmission to control hippocampal synaptic plasticity

CORTICAL GLUTAMATERGIC AND GABAergic SYNAPTIC NEUROTRANSMISSION

Membrane-Derived Phospholipids Control Synaptic Neurotransmission and Plasticity

Synaptic communication is a dynamic process that is key to the regulation of neuronal excitability and information processing in the brain. To date, however, the molecular signals controlling synaptic dynamics have been poorly understood. Membrane-derived bioactive phospholipids are potential candidates to control short-term tuning of synaptic signaling, a plastic event essential for informatio...

Glutamatergic Neurotransmission Links Sensitivity to Volatile Anesthetics with Mitochondrial Function

An enigma of modern medicine has persisted for over 150 years. The mechanisms by which volatile anesthetics (VAs) produce their effects (loss of consciousness, analgesia, amnesia, and immobility) remain an unsolved mystery. Many attractive putative molecular targets have failed to produce a significant effect when genetically tested in whole-animal models [1-3]. However, mitochondrial defects i...

Synaptic and extrasynaptic plasticity in glutamatergic circuits

36 37 Chronic global N-methyl-D-aspartate receptor (NMDAR) blockade leads to changes in 38 glutamatergic transmission. The impact of more subunit-selective NMDAR inhibition on glutamatergic 39 circuits remains incomplete. To this end organotypic hippocampal slice cultures were treated for 17-21 40 days with the: high-affinity competitive antagonist D-APV, allosteric GluN2B-selective antagonist ...

Synaptic plasticity: hippocampal LTP.

One of the most intensively studied forms of synaptic plasticity is long-term potentiation (LTP). The past year has seen further evidence advanced on both sides of the presynaptic/postsynaptic locus of expression debate, without an obvious path to reconcile the two views. Real progress has been made, however, in clarifying the possible role of nitric oxide as a retrograde messenger and the cell...